K74.6 K70.3
Conditions
Interventions
Group 1: patients with liver cirrhosis
Sponsors
Universitätsmedizin Rostock, Department für Innere Medizin, Klinik und Poliklinik für Gastroenterologie, Hepatologie und Ernährungsmedizin
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - confirmed liver cirrhosis - consent ability
Exclusion criteria
Exclusion criteria: - Unable or unwilling to attend follow-up appointments or unable to answer questionnaires (lack of mobility, lack of compliance, e.g., due to uncontrolled search disease) - concomitant disease (COPD GOLD 3 or 4, heart failure NYHA 3 or 4, foreseeable need for major surgery) - Active tumor disease including HCC (pre-existing malignant tumors or reasonable suspicion (e.g., hepatic lesions LIRADS 3 or 4); curatively treated tumors including HCC with no evidence of recurrence for >3 years and non-melanotic skin cancer are not exclusion criteria) - Criteria of an ACLF fulfilled - Diseases affecting musculoskeletal or joint function (e.g., apoplexy with paresis) - Condition after major amputations - History of eating disorders (e.g., anorexia nervosa, bulimia) - Restricted food intake or absorption due to other conditions (e.g., achalasia, feeding via PEG, need for special diets (phenylketonuria), short bowel syndrome) - Cardiac pacemaker/ defibrillator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Death (of any cause), liver transplantation, unplanned inpatient admission for complications of cirrhosis | — |
Secondary
| Measure | Time frame |
|---|---|
| In the longitudinal study, various examination procedures (questionnaires, anthropometry, hand grip strength, walking speed, bioelectrical impedance analysis (BIA), clinical chemistry, myokinassays, and MRI imaging in patients with TIPS insertion) for sarcopenia and malnutrition diagnosis will be performed at several measurement time points (study inclusion, after 6, and 12 months). Secondary endpoints include changes in parameters assessed by the methods described. | — |
Countries
Germany
Contacts
Public ContactGeorg Lamprecht
Universitätsmedizin Rostock, Department für Innere Medizin, Klinik und Poliklinik für Gastroenterologie, Hepatologie und Ernährungsmedizin
Outcome results
None listed