M62.5
Conditions
Interventions
Group 1: The project is a collaboration with the European Space Agency (ESA), the University of Trieste in Italy (PI, Dr. Alessandra Bosutti), Manchester Metropolitan University in the UK (Prof. Dr. H
n= 8 desired) will use an intervention with neuromuscular electrostimulation in addition to their current training during their stay on the ISS. The control group (n=6 required
n= 8 desired) will not use this intervention. There are a number of pre-, in- and post-flight experiments that are used to investigate the effectiveness of the intervention. These experiments are iden
Sponsors
Universität Trieste
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Astronauts from ESA, NASA, the Japanese or Canadian space agencies flying to the ISS.
Exclusion criteria
Exclusion criteria: - Subjects with ferromagnetic metal implants, pacemakers or electronic materials cannot be included in the study due to the MRI scan - Previous head surgery with metal implants - Claustrophobia - Previous knee surgery or ligament injuries - Personal or family history of epilepsy, uncontrolled high blood pressure, bleeding tendency, use of aspirin or warfarin, impaired blood clotting, history of nerve, muscular or skeletal disorders of the leg - Allergies to kinesiology tape, stickers, electrode gel or Aquasonic ultrasound gel - Cardiac diseases - Pregnant women - MRI cannot be performed on persons with: Implanted pacemakers Intracranial aneurysm clips Cochlear implants Certain prosthetic devices Implanted drug infusion pumps Neurostimulators Bone growth stimulators Certain intrauterine contraceptive devices (e.g. with iron-based metal) All other types of iron-based metal implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurements before and immediately after spaceflight of: - Muscle neuromuscular functions (muscle strength, fatigue resistance, voluntary activation capacity, motor unit function), muscle volume and architecture (MRI) - Muscle perfusion (SO2, blood flow, Hb content) measured with NIRS and O2C - Maximum oxygen uptake (V'O2) and maximum CO2 release (V'CO2) - Blood analyses: circulating myokines, microRNAs, inflammatory and angiogenesis biomarkers, parameters of neuromuscular interaction, muscle physiology, etc. - Questionnaires (muscular symptoms, previous diseases etc.) | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of the degree of muscular degradation due to the stay in weightlessness between the intervention and control groups | — |
Countries
Canada, Germany, Japan, United States
Contacts
Public ContactAlessandra Bosutti
Universität Trieste
Outcome results
None listed