G12.2
Conditions
Interventions
Group 1: Observational study-Patients with sporadic ALS (sALS), which refers to those without a family history of ALS, are typically not subjected to genetic investigations as part of their standard c
Sponsors
Ambulanzpartner Soziotechnologie APST GmbH
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: ALS, including classical ALS, Progressive Muscle atrophy (PMA) or Primary Lateral Sclerosis (PLS) Ability to understand the purpose and risks of the study and provide signed and dated informed consent and authorization to use protected health information (PHI) under national and local subject privacy regulations Age of 18 years old at the time of informed consent
Exclusion criteria
Exclusion criteria: Inability to provide patient directives about the notification of individual study results on genetic variants of SOD1, C9orf72, FUS and TARDBP Inability to comply with study requirements Unspecified reasons that, in the opinion of the site investigator, perceive the subject as unsuitable for enrollment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| •To identify the frequency of genetic variants in the genes of SOD1, C9orf72, FUS and TARDBP in patients with sALS and fALS-Study subjects will have up to 3 assessments, with a 4-month interval for approximately one year. | — |
Secondary
| Measure | Time frame |
|---|---|
| •To investigate the demographic and social characteristics •To investigate the family history for ALS or FTD •To investigate the clinical classification, functional deficits and progression | — |
Countries
Germany
Contacts
Public ContactThomas Meyer
CHARITÉ - UNIVERSITÄTSMEDIZIN BERLIN
Outcome results
None listed