ICD10: F12.9
Conditions
Interventions
Group 1: Patients with a history of cannabis use and positive urine test for THC who are scheduled for a procedure under general anesthesia.
Group 2: Patients with no history of cannabis use and negat
Sponsors
Universitätsklinikum der Goethe Universität Frankfurt am Main
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: ASA 1-3, induction anesthetic is propofol, elective surgery.
Exclusion criteria
Exclusion criteria: BMI >35 or <17; acute intoxication on rapid urine test or history), history of alcohol abuse, pregnancy or lactation, ingestion of other psychoactive substances within the past few days with positive urine drug screen, history of opiate dependence, history of benzodiazepine use in the past 24h. Anesthetics for induction of general anesthesia other than propofol and fentanyl.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of propofol to achieve general anesthesia with loss of responsiveness . | — |
Secondary
| Measure | Time frame |
|---|---|
| -TCH concentration in serum in the perioperative period - Level of THC degradation products in urine in perioperative period - concentration of PETh and EtG in blood - vital signs - processed and unprocessed frontal EEG parameters of anesthesia monitoring - parameters of heart rate variability from ECG - Postoperative pain level (NRS/VAS) - Preoperative anxiety level (STOA) - Postoperative nausea (frequency) - PACU delirium (3D-CAM) - Time to discharge - Perioperative analgesic requirement | — |
Countries
Germany
Contacts
Public ContactSebastian Zinn
Universitätsklinikum der Goethe Universität Frankfurt am am Main
Outcome results
None listed