DSM-5 Alcohol Use Disorder
Conditions
Interventions
Group 1: Women with alcohol use disorder (AUD) are studied continuously over a period of three menstrual cycles via smartphone entries and attend comparative laboratory sessions during the ovulatory c
Sponsors
Zentralinstitut für Seelische Gesundheit (ZI)
Eligibility
Sex/Gender
Female
Age
18 Years to 42 Years
Inclusion criteria
Inclusion criteria: - Female sex at birth - Regular menstrual cycle with a duration between 21 and 35 days in the last three months - Body mass index 18.5-30.0 kg/m² - AUD according to DSM-5 (American Psychiatric Association, 2013) - Ability to give informed written consent and to undergo functional magnetic resonance imaging - Written Informed Consent available - Sufficient knowledge of the German language - Breath alcohol concentration of 0.0 per mille
Exclusion criteria
Exclusion criteria: - Medical history of bipolar disorder, psychotic disorder, schizophrenia or schizophrenic spectrum disorder, or substance use disorder other than alcohol, nicotine, or cannabis, treated as an outpatient or inpatient - History of severe head injury or other severe central nervous system disease (e.g., dementia, Parkinson's disease, multiple sclerosis) - Intake of drugs or medications that interact with the central nervous system within the last 10 days or if their use was less than 5 half-lives in the past - Intake of contraceptives or other hormones that affect the menstrual cycle - Breastfeeding - Active wish to become pregnant - Exclusion criteria for an MRI examination - Known intolerance to high-frequency flickering visual stimuli - Presence of premenstrual dysphoric disorder according to SIPS
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alcohol craving (smartphone and laboratory assessment) | — |
Secondary
| Measure | Time frame |
|---|---|
| Daily to weekly smartphone entries in real-life - Alcohol consumption - Control ability - Social contacts - Mood / depressiveness - Mindfulness - Gender roles - Drinking motives fMRI - Alcohol cue reactivity (Alcue task) - Reactivity in a behavioral inhibition task (Stop-signal task) - Emotion processing (Hairiri task) - Resting state synchronicity Virtual reality/ in vivo exposure to alcoholic stimuli - Attentional bias (Dot probe task, alcohol Stroop task) | — |
Countries
Germany
Contacts
Public ContactLeonard P. Wenger, M.Sc.
Zentralinstitut für Seelische Gesundheit (ZI)
Outcome results
None listed