Effects of high- versus LOw-intensity lipid-lowering treatment in patients undergoing serial CoronAry compuTEd tomography angiography: Results of the multi-center LOCATE study

Effects of high- versus LOw-intensity lipid-lowering treatment in patients undergoing serial CoronAry compuTEd tomography angiography: Results of the multi-center LOCATE study - LOCATE

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00031954

Enrollment

300

Registered

2023-06-12

Start date

2023-01-02

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I25

Interventions

Group 1: Retrospective analysis of all patients with suspected or known CHD and clinical indication for serial CCTA without lipid-lowering therapy or with low-intensity lipid-lowering therapy between

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Availability of images from at least 64-slice cardio-CT scanner. Documentation of lipid-lowering therapy at time of serial cardio-CT scan.

Exclusion criteria

Exclusion criteria: Pregnancy/Lactation. Patients without atherosclerotic lesions at baseline and follow-up. Patients undergoing PCI or CABG between the 2 CCTA scans.

Design outcomes

Primary

Measure	Time frame
Serial quantitative evaluation of plaque burden and composition in patients with no/low versus moderate and high-dose lipid-lowering therapy. Evaluation of the impact of different intensities of lipid-lowering treatment on high-risk plaque features and pericoronary adipose tissue attenuation (PCAT)	—

Secondary

Measure	Time frame
Verification of results by analysis of inter- and intraobserver (>4 weeks) variability.	—

Countries

Germany, Hungary, Switzerland

Contacts

Public ContactGrigorios Korosoglou

GRN-Klinikum Weinheim

gkorosoglou@hotmail.com06201 89-2142

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 6, 2026