Monitoring of wound and fracture healing and prediction of non-union via measurements of microcirculation

Monitoring of wound and fracture healing and prediction of non-union via measurements of microcirculation - Fracture perfusion

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00031942

Enrollment

100

Registered

2023-05-22

Start date

2022-10-24

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

S82 S42

Interventions

Group 1: Patients with bone fractures (tibia fracture, clavicle fracture or patella fracture). The microcirculation in and around the fracture gap is measured, as is the microcirculation in the corres

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Bone fracture (Tibia, clavicle, patella) Ability for written and verbal informed consent

Exclusion criteria

Exclusion criteria: Underage Inabilita to give consent

Design outcomes

Primary

Measure	Time frame
RHb, SO2 and tissue blood flow at 3, 8, 10, 12, 14 and 16 mm depth. NIRS parameters O2Hb, HHb, tHb, HbDiff und TSI. In addition skin temperature.	—

Secondary

Measure	Time frame
1. effect of i.v. administration of noradrenaline on perfusion in the fracture gap, 2. to assess whether the measurement can be made only in the fracture gap or also 2 cm away from it, 3. clarification of whether microcirculation measurements can be used to predict the development of pseudarthrosis, 4. definition of the physiological changes in the above parameters in the course of fracture healing.	—

Measure

Time frame

1. effect of i.v. administration of noradrenaline on perfusion in the fracture gap, 2. to assess whether the measurement can be made only in the fracture gap or also 2 cm away from it, 3. clarification of whether microcirculation measurements can be used to predict the development of pseudarthrosis, 4. definition of the physiological changes in the above parameters in the course of fracture healing.

—

Countries

Germany

Contacts

Public ContactBergita Ganse

Universität des Saarlandes

bergita.ganse@uks.eu+4968411631570

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026