Striatal dopamine and volitional motor control: vigour, planning, and incentive salience

Striatal dopamine and volitional motor control: vigour, planning, and incentive salience - Dopamine and motor control

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00031846

Enrollment

140

Registered

2023-06-01

Start date

2021-07-01

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G20

Interventions

Group 1: Patients with Parkinson's disease Data collection: neuropsychological testing, motor function tests, MRI Intervention: no Follow-up: no Group 2: Prodromal Parkinson's disease patients Data co

Eligibility

Sex/Gender

All

Age

50 Years to 80 Years

Inclusion criteria

Inclusion criteria: Healthy controls: - Right-Handedness Prodromal group: - Right-Handedness - Diagnosis according to the MDS research criteria (Berg) - DaT SPECT Parkinson’s disease group: - Right-Handedness - Diagnosis according to the MDS clinical diagnostic criteria (Postuma) - DaT SPECT - Clinical symptoms < 3 years - Hoehn and Yahr <= 3

Exclusion criteria

Exclusion criteria: All groups: - Depression - Cognitive deficits - Significant comorbidities - Contraindications for MRI - Intake of serotonin reuptake inhibitors

Design outcomes

Primary

Measure	Time frame
Examine the consequences of dopamine loss and motor reserve on volitional motor control in the domains of movement vigor, motor planning, and the incentive salience of movements.	—

Secondary

Measure	Time frame
Structural and functional neural circuits and neurotransmitters.	—

Countries

Germany

Contacts

Public ContactMerle Hoenig

Uniklinik Köln, Klinik für Nuklearmedizin

merle.hoenig1@uk-koeln.de+49 221 478 82837

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 14, 2026