Perioperative concentrations of reactive oxygen species in the cerebrospinal fluid of neurosurgically treated patients

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00031776

Enrollment

Registered

2024-07-05

Start date

2024-07-01

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

redox processes

Interventions

Group 1: Patients undergoing a therapeutic lumbar puncture for normal pressure hydrocephalus

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - patients receiving a CSF puncture

Exclusion criteria

Exclusion criteria: a) All patients who are younger than 18 years old b) Patients who do not agree to the research project c) CSF samples from which, directly or indirectly, there is a diagnostic or therapeutic consequence for the patient in question d) CSF samples that would not be immediately discarded, destroyed or disposed of without the present research project e) Contain an amount of less than 5 milliliters. f) Are visibly contaminated by blood or foreign substances. g) Are cloudy or have precipitates. h) show signs of an inflammatory change.

Design outcomes

Primary

Measure	Time frame
Determination and differentiation of the concentration of reactive oxygen species (including hydrogen peroxide (H2O2)) in the cerebrospinal fluid	—

Secondary

Measure	Time frame
Verification of the suitability of electron spin resonance and the Amplex™ Red hydrogen peroxide/peroxidase assay for the determination of reactive oxygen species (including hydrogen peroxide (H2O2)) from cerebrospinal fluid	—

Countries

Germany

Contacts

Public ContactFriedhelm Beyersdorf

Universitätsklinikum Freiburg

friedhelm.beyersdorf@uniklinik-freiburg.de+4976127061960

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 14, 2026