Oral microbiome of children with molar-incisor hypomineralization compared to healthy children - A pilot study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00031756

Enrollment

100

Registered

2023-05-15

Start date

2023-04-27

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K00.4

Interventions

Group 1: Children with molar-incisor hypomineralization (MIH) For the examination of the oral microbiome, one saliva sample and one dental biofilm sample per child collected during one appointment wil

Eligibility

Sex/Gender

All

Age

7 Years to 12 Years

Inclusion criteria

Inclusion criteria: Seven to 12-year-old children Children without cavitated carious lesions Children with MIH Written informed consent to participate

Exclusion criteria

Exclusion criteria: Systemic diseases Temporary / permanent medication Intake of antibiotics within the last three months Hypomineralization because of other reasons than MIH Cavitated carious lesions present in the oral cavity

Design outcomes

Primary

Measure	Time frame
Oral microbiome in children with and without MIH assessed by next-generation sequencing (NGS) of saliva and biofilm samples	—

Secondary

Measure	Time frame
Correlation of clinical parameters (MIH severity, plaque index, gingival index) with the composition of the oral microbiome	—

Countries

Germany

Contacts

Public ContactStefanie Amend

Justus-Liebig-Universität Gießen, MZZMKH, Poliklinik für Kinderzahnheilkunde

Stefanie.Amend@dentist.med.uni-giessen.de+49-641-99-46241

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026