G20
Conditions
Interventions
Group 1: Patients who have had a 123I-FP-CIT SPECT examination for differential diagnosis of Parkinson's disease.
Sponsors
Klinik für Neurologie
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: Parkinson's syndrome or unclear tremor syndrome (which led to referral to nuclear medicine for FP-CIT SPECT examination). Signing of the consent form
Exclusion criteria
Exclusion criteria: - Non-consent or inability to consent to study participation. - Alcohol/drug abuse (current or history) - acute psychotic symptoms - Relevant previous ophthalmologic disease (high-grade visual loss, age-related macular degeneration, glaucoma) - relevant cognitive impairment (MOCA score < 18) - severe previous internal disease (e.g. cardiac insufficiency) or orthopedic/rheumatologic previous disease interfering with the planned examinations - Pregnancy according to self-disclosure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is whether there is a correlation between the extent of dopaminergic deficit and changes in retinal nerve fiber thickness. | — |
Secondary
| Measure | Time frame |
|---|---|
| Relationships between striatal dopaminergic neurodegeneration and already established biomarkers of Parkinson's disease (transcranial sonography and olfactory test) as well as possible differences in the collected questionnaires between patients with and without evidence of a dopaminergic deficit. | — |
Countries
Germany
Contacts
Public ContactJost-Julian Rumpf
Klinik für Neurologie
Outcome results
None listed