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Systemic effects of the pathological germ spectrum of the oral cavity of children and adolescents (0-18 years) with caries - a pilot study

Systemic effects of the pathological germ spectrum of the oral cavity of children and adolescents (0-18 years) with caries - a pilot study - CAMB

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00031726
Enrollment
200
Registered
2023-05-04
Start date
2023-05-04
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K02.9 K04.6 Q24.9

Interventions

Group 1: Children and adolescents aged 0-18 years with caries with general disease and with manifestation of dentogenic fistula/(incipient) dentogenic abscess who need to undergo oral rehabilitation u
culture and microbial DNA analysis) o Collection of 2 blood samples (CRP & microbiome analysis) 2nd appointment (follow-up appointment 3 months after oral rehabilitation under anaesthesia): o Detaile
culture and microbial DNA analysis) Group 2: Children and adolescents aged 0-18 years with caries without general disease and without manifestation of a dentogenic fistula/(incipient) dentogenic absce
culture and microbial DNA analysis) o Collection of 2 blood samples (CRP & microbiome analysis) 2nd appointment (follow-up appointment 3 months after oral rehabilitation under anaesthesia): o Detailed
culture and microbial DNA analysis) Group 3: Children and adolescents aged 0-18 years with caries without general disease and with manifestation of a dentogenic fistula/(incipient) dentogenic abscess

Sponsors

Poliklinik Kinderzahnheilkunde
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 18 Years

Inclusion criteria

Inclusion criteria: Present and signed certificate of consent from parents or legal guardians.

Exclusion criteria

Exclusion criteria: Children without valid declaration of consent by parents or legal guardians.

Design outcomes

Primary

MeasureTime frame
DMFT value By means of a hypothesis-based evaluation, within the framework of a prospective randomised study, it is to be investigated whether there is a connection between an altered oral flora and the occurrence of a general infection.

Secondary

MeasureTime frame
Abscess/fistula

Countries

Germany

Contacts

Public ContactNorbert Krämer

Poliklinik Kinderzahnheilkunde

maria.hofmann2@dentist.med.uni-giessen.de06419946241

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026