Retrospective analysis of blood biomarkers in cardiac surgery patients with postoperative neurocognitive disorders and sub-clinical brain infarcts

Retrospective analysis of blood biomarkers in cardiac surgery patients with postoperative neurocognitive disorders and sub-clinical brain infarcts - BICAPONI

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00031711

Enrollment

Registered

2023-11-09

Start date

2023-08-07

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative cognitive decline

Interventions

Group 1: Retrospective analysis of perioperatively obtained blood from patients undergoing elective cardiac surgery using extracorporeal circulation.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Elective cardiac surgery (on pump) a. Aortic valve replacement (AVR) b. Mitral valve replacement/reconstruction (MVR) c. Combination (Coronary artery bypass grafting (CABG)+AVR, CABG+MVR, AVR+MVR, CABG+AVR+MVR) 2. Sufficient knowledge of the German language, as the neuropsychological tests are language-dependent 3. Written informed consent of the patients to participate in the studies 4. Available biomaterial

Exclusion criteria

Exclusion criteria: - previous cardiac surgery - preoperative psychiatric illness (dementia, depression) with acute symptoms that could interfere with neuropsychological testing - preoperative neurological diseases (stroke) with acute symptoms that could interfere with neuropsychological testing

Design outcomes

Primary

Measure	Time frame
Which blood biomarkers are associated with the development of postoperative cognitive decline (POCD) in both patients with and without postoperative subclinical brain infarcts?	—

Secondary

Measure	Time frame
1. Which blood biomarkers are associated with the development of postoperative delirium (POD) in both patients with and without postoperative subclinical brain infarcts? 2. Which blood biomarkers are associated with the development of postoperative subclinical brain infarcts? 3. Which blood biomarkers are associated with the development of postoperative cognitive increase (POCI) in both patients with and without postoperative subclinical brain infarcts? 4. What is the role of blood biomarkers and chronic preexisting cerebral white matter damage in the development of POCD in both patients with and without postoperative subclinical brain infarcts? 5. What is the role of blood biomarkers and chronic preexisting cerebral white matter damage in the development of POD in both patients with and without postoperative subclinical brain infarcts? 6. Which blood biomarkers are associated with worsened outcomes in postoperative health-related quality of life in both patients with and without postoperative subclinical brain infarcts? 7. Which blood biomarkers are associated with the development of postoperative subjectively assessed cognitive failures in daily living in both patients with and without postoperative subclinical brain infarcts? 8. Which blood biomarkers are associated with development of postoperative depression in both patients with and without postoperative subclinical brain infarcts? 9. Which blood biomarkers are associated with the amount of anesthetic? 10. Which blood biomarkers are associated with longer ICU length of stay in both patients with and without postoperative subclinical brain infarcts? 11. Which blood biomarkers are associated with longer length of stay in the normal ward in both patients with and without postoperative subclinical brain infarcts?	—

Measure

Time frame

1. Which blood biomarkers are associated with the development of postoperative delirium (POD) in both patients with and without postoperative subclinical brain infarcts? 2. Which blood biomarkers are associated with the development of postoperative subclinical brain infarcts? 3. Which blood biomarkers are associated with the development of postoperative cognitive increase (POCI) in both patients with and without postoperative subclinical brain infarcts? 4. What is the role of blood biomarkers and chronic preexisting cerebral white matter damage in the development of POCD in both patients with and without postoperative subclinical brain infarcts? 5. What is the role of blood biomarkers and chronic preexisting cerebral white matter damage in the development of POD in both patients with and without postoperative subclinical brain infarcts? 6. Which blood biomarkers are associated with worsened outcomes in postoperative health-related quality of life in both patients with and without postoperative subclinical brain infarcts? 7. Which blood biomarkers are associated with the development of postoperative subjectively assessed cognitive failures in daily living in both patients with and without postoperative subclinical brain infarcts? 8. Which blood biomarkers are associated with development of postoperative depression in both patients with and without postoperative subclinical brain infarcts? 9. Which blood biomarkers are associated with the amount of anesthetic? 10. Which blood biomarkers are associated with longer ICU length of stay in both patients with and without postoperative subclinical brain infarcts? 11. Which blood biomarkers are associated with longer length of stay in the normal ward in both patients with and without postoperative subclinical brain infarcts?

—

Countries

Germany

Contacts

Public ContactMarius Butz

Kerckhoff-Klinik, Heart and Brain Research Group

m.butz@kerckhoff-klinik.de+49(0)6032/996 5812

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026