K05.3 K05.1
Conditions
Interventions
Group 1: Participants in the Optifast fasting program at the University Hospital Heidelberg.
Description of the intervention: Initially, for 12 weeks, maximum of 800kcal per day, exclusively Optifast
Sponsors
Universitätsklinik Heidelberg, MZK-Klinik, Abteilung für Zahnerhaltungskunde
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Ability to give consent - Planned participation in the "Optifast®" program, inclusion criterion BMI =30kg/m2.
Exclusion criteria
Exclusion criteria: - Antibiotic intake in the last 6 months - Use of medications that may affect (gingival) inflammation - Presence of severe general diseases including diseases with high risk of endocarditis, immunosuppression and present infectious diseases (HIV)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relative proportion of sites with periodontal bleeding on brobing, three and six months after baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in periodontal probing depths, clinical attachment loss, gingival bleeding, subgingival microbiome, gut microbiome, gingival crevicular fluid flow rate, cytokine composition in gingival crevicular fluid, other standard laboratory parameters, levels of volatile sulfur compounds in breath, quantity of tongue coating - all after three and six months. In addition, the change of dietary habits after six months. | — |
Countries
Germany
Contacts
Public ContactValentin Bartha
Universitätsklinik Heidelberg, MZK-Klinik, Abteilung für Zahnerhaltungskunde
Outcome results
None listed