Prospective observational clinical study to investigate the oral cavity microbiome in patients with depression treated with selective serotonin reuptake inhibitors (SSRIs)

Prospective observational clinical study to investigate the oral cavity microbiome in patients with depression treated with selective serotonin reuptake inhibitors (SSRIs) - Dep_Microbiom

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00031660

Enrollment

Registered

2023-04-17

Start date

2022-11-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F33.8

Interventions

Group 1: Patients have diagnosed depression and are receiving SSRI continuous medication Group 2: Patients have diagnosed depression and are not receiving SSRIs (SRNIs)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with or without SSRIs as permanent medication Patients diagnosed with depression

Exclusion criteria

Exclusion criteria: - Patient is undergoing active periodontal treatment - Increased tobacco consumption (>10 cigarettes per day) - Patients with a disease that may affect the periodontium (e.g. diabetes mellitus, chronic inflammatory bowel disease) - Poor general condition that does not allow dental diagnosis (retardation, dementia)

Design outcomes

Primary

Measure	Time frame
Does an altered oral cavity microbiome show up in patients on SSRI medication	—

Secondary

Measure	Time frame
Clinical parameters correlating with disease and PA Probing depths PD (6 pages); Pardontal Screening Index PSI. O: 3.5mm PD to 5.5mm 4:>5.5mm Bleeding on probing BOP Suppuration Recession Percussion Clinical attachment loss CAL Degree of loosening Plaque Index according to Mombelli (PI) Grade 0: no plaque detectable by inspection and probing Grade 1: accumulation of plaque visible only by probing in the sulcus with a probe but not by eye Grade 2: visible plaque accumulation Grade 3: massive plaque accumulation	—

Measure

Time frame

Clinical parameters correlating with disease and PA Probing depths PD (6 pages); Pardontal Screening Index PSI. O: 3.5mm PD to 5.5mm 4:>5.5mm Bleeding on probing BOP Suppuration Recession Percussion Clinical attachment loss CAL Degree of loosening Plaque Index according to Mombelli (PI) Grade 0: no plaque detectable by inspection and probing Grade 1: accumulation of plaque visible only by probing in the sulcus with a probe but not by eye Grade 2: visible plaque accumulation Grade 3: massive plaque accumulation

—

Countries

Germany

Contacts

Public ContactMayte Buchbender

Mund-Kiefer- und Gesichtschirurgische Klinik, FAU Uniklinik Erlangen

mayte.buchbender@uk-erlangen.de09131-8533614

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026