Advancing methodology for determination of free plasma concentrations of drugs by HPLV-UV after ultrafiltration

Advancing methodology for determination of free plasma concentrations of drugs by HPLV-UV after ultrafiltration - UF-fU

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00031635

Enrollment

500

Registered

2023-04-06

Start date

2023-05-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Method to determine the plasma protein binding rate of drugs.

Interventions

Group 1: This clinical study will investigate and advance a methodology of determination of free plasma concentrations of drugs by HPLV-UV after ultrafiltration. To that end, residual biological sampl

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Residual Material can be obtained without intervention at the patient 2. Patient is under therapy with one of the target substances, irrespective of the study, OR a patient with abnormal values of covariates with potential influence to plasma protein binding rate (e.g. albumine)

Exclusion criteria

Exclusion criteria: n/a

Design outcomes

Primary

Measure	Time frame
Determination of the total and free plasma concentrations of drugs (f.i. Vancomycin)	—

Secondary

Measure	Time frame
Determination of the influence of certain covariates to plasma protein binding rate.	—

Countries

Germany

Contacts

Public ContactAlexander Dejaco

Universitätsklinikum Regensburg

alexander.dejaco@ukr.de0944 941 7801

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026