G12.2 G31.0
Conditions
Interventions
Group 1: Patients with ALS/FTD and healthy controls are called four times within one year by automated call or by a study staff member. Tasks on cognition, speech motor skills and breathing are perfor
Sponsors
DZNE Rostock/Greifswald
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Participant in DESCRIBE-ALS or -FDT oder DANCER Presence of either ALS or FTD (PPA, bvFTD) (46)) Sufficient knowledge of German to understand participant information, consent form, and questionnaires. Independent ability to give consent or consenting caregiver(s) signed and dated informed consent form
Exclusion criteria
Exclusion criteria: no participant in DESCRIBE-ALS or -FDT oder DANCER Significantly impaired hearing extinguished ability to communicate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective of PROSA is to create an easy-to-perform digital speech-based assessment battery that serves as the best proxy possible for cognitive, respiratory, and motor domains and on this battery the validation of a new prognostic language biomarker for the ALS-FTD spectrum. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objective of the study is to investigate prognostic models based on clinical outcomes at 12-months follow up. Another outcome is to test the user acceptance of automated calls and the feasibility of speech testing by telephone. | — |
Countries
Germany
Contacts
Public ContactMartha;Judith Kring;Baltes
DZNE Rostock/Greifswald;DZNE Bonn
Outcome results
None listed