Measurement of the concentrations of lithium, sodium, potassium and creatinine in the saliva of patients with treatment-resistant depression.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00031566

Enrollment

Registered

2023-03-29

Start date

2023-05-24

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F32 F31

Interventions

Group 1: Patients undergoing inpatient and outpatient treatment and patients in neurology Group 2: Patients with lithium intoxication

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: -Diagnosis of Unipolar Depression or Bipolar Disorder (I and II). -Existing or planned lithium therapy in inpatient and outpatient treatment -Existing capacity to give consent -Existence of written informed consent

Exclusion criteria

Exclusion criteria: -Diagnosis of antisocial or other severe personality disorder. -Schizophrenia -Severe cognitive impairment e.g. dementia or severe intelligence impairment -Withdrawal of informed consent -Existing renal insufficiency stage 3 and above (GFR 30-59), severe cardiac or circulatory disease -Institutionalization by court or official order (according to AMG § 40 (1) 4).

Design outcomes

Primary

Measure	Time frame
Investigation of the correlation between lithium, sodium and creatinine concentrations in venous blood, whole blood and saliva over the period of one year with at least four measurements.	—

Secondary

Measure	Time frame
Determination of the potential of saliva as a more accessible and less invasive medium for the determination of lithium concentration	—

Countries

Germany

Contacts

Public ContactPichit Buspavanich

Medizinische Hochschule Brandenburg

pichit.buspavanich@mhb-fontane.de0339139-2110

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 7, 2026