Effect of the timing of antibiotic prophylaxis before gastrointestinal and vascular surgery with laparotomy on the incidence of incisional hernias

Effect of the timing of antibiotic prophylaxis before gastrointestinal and vascular surgery with laparotomy on the incidence of incisional hernias - ANTINA

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00031551

Enrollment

450

Registered

2023-05-05

Start date

2023-03-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K43.0 K43.1 K43.2

Interventions

Group 1: The study includes patients who have undergone gastrointestinal or vascular surgery with laparotomy between 1 January 2018 and 31 December 2020 at the University Medical Center Halle (Saale).

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: • Gastrointestinal or vascular surgery with laparotomy (midline incision, transverse incision, subcostal incision, Pfannenstiel incision) • Surgery in the period from 1 January 2018 to 31 December 2020 • Surgery was planned

Exclusion criteria

Exclusion criteria: • Absent ability to provide informed consent • A utilitiy incision to remove the resection specimen during a laparoscopic procedure is not considered a laparotomy • Re-laparotomy within 30 days after primary surgery • Conversion to laparotomy during laparoscopic surgery

Design outcomes

Primary

Measure	Time frame
Time to the occurrence of incisional hernia after primary surgery	—

Secondary

Measure	Time frame
• Incidence of incisional hernia throughout the postoperative period up to the time of data collection • Therapeutic relevance of a developed incisional hernia (none, symptomatic treatment, surgery) • Frequency of hospital readmissions due to complications caused by incisional hernia • Occurrence of a postoperative fascial dehiscence • Frequency and severity of postoperative complications (according to the Clavien-Dindo-Classification) • Frequency and severity of SSI (Surgical Site Infection, severity according to CDC-Classification) • Frequency, timing and reason for a re-laparotomy after primary surgery	—

Measure

Time frame

• Incidence of incisional hernia throughout the postoperative period up to the time of data collection • Therapeutic relevance of a developed incisional hernia (none, symptomatic treatment, surgery) • Frequency of hospital readmissions due to complications caused by incisional hernia • Occurrence of a postoperative fascial dehiscence • Frequency and severity of postoperative complications (according to the Clavien-Dindo-Classification) • Frequency and severity of SSI (Surgical Site Infection, severity according to CDC-Classification) • Frequency, timing and reason for a re-laparotomy after primary surgery

—

Countries

Germany

Contacts

Public ContactFranziska Pommer

Universitätsklinikum Halle (Saale)

franziska.pommer@t-online.de+49 345 557 2314

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026