Changes in differential blood counts, parameters of the immune system and intestinal microbiome
Conditions
Interventions
Group 1: An eight-week vegan dietary intervention that excludes all animal products.
Group 2: An eight-week meat-rich dietary intervention that includes at least 150 grams of animal flesh (meat) per d
Sponsors
Universitätsklinikum Freiburg - Klinik für Innere Medizin II - Unizentrum Naturheilkunde
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Men and women aged 18 to 60 years with a body mass index (BMI) between 21 kg/m2 and 30 kg/m2 will be included in our study.
Exclusion criteria
Exclusion criteria: Pregnancy and breast feeding period Regular intake of medication (except for iodine and contraceptives) Chronic diseases (including but not limited to): diabetes mellitus, rheumatoid arthritis, hypertension, cardiac diseases, chronic immune diseases (variable immunodeficiency syndrome). Pronounced allergies (which requires the intake of regular medication during the allergy season) Vegans, vegetarians, aversion to meat-rich or vegan diets Eating disorders, food intolerance (e.g. fructose intolerance, gluten intolerance) and pronounced food allergies Abuse of drugs, alcohol (>20g/day) or nicotine (daily cigarette consumption) Participation in another clinical study within the last four weeks Blood donations in the last four weeks Any clinical finding that makes the participant appear unsuitable for the course of the study (based on the judgment of the study's PI) Manifest infection within the last two weeks Pre-existing psychiatric conditions that are incompatible with group interventions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in the neutrophil count after an 8-week dietary intervention (vegan vs. meat-rich). | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the following parameters after an eight-week dietary intervention: Changes in the lymphocyte count Changes in the monocyte count Changes in arachidonic acid or eicosanoids in the urine Differentiation of lymphocytes including (CD3 T cells, CD4 T helper cells, CD8 cytotoxic T cells, CD19 B cells and CD16/CD56 NK cells) Changes in the differential blood count Changes in vitamin D metabolism Changes in Vitamin B12-metabolism, as assessed by the cB12-index by Fedosov et al. - a mathematical model combining four markers (total B12, holotranscobalamin (holoTC, Active-B12), homocysteine and methylmalonic acid (MMA) Changes in the amino acid metabolism Changes in the microbiological profile of the gut microbiome Changes in microbiome metabolites (in particular Glutamine, Leucine, TMAO, Acetate, Glucose, Glycerin, and Cobalamin Analogs) Changes in the dietary intake and in the macro- and micronutrient distribution / dietary intervention effects on diet quality indices Changes in defecation patterns using the Bristol Stool Scale / gastrointestinal quality of life index according to Eypasch | — |
Countries
Germany
Contacts
Public ContactMaximilian Storz
Universitätsklinikum Freiburg - Klinik für Innere Medizin II - Unizentrum Naturheilkunde
Outcome results
None listed