Ex vivo investigation of neuronal signal processing in networks of the human cortex

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00031537

Enrollment

Registered

2023-05-05

Start date

2020-02-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Invenstigation of physiologiscal mechanisms of plasticity

Interventions

Group 1: pharmacologic/metabolic/electric/magnetic induction of plasticity Group 2: Control group The control tissue will undergo ex vivo "sham" treatments (e.g., treatment with carrier substance with

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Neocortical access tissue that was tranfered to the biobank of the deparment of neurosurgery

Exclusion criteria

Exclusion criteria: none

Design outcomes

Primary

Measure	Time frame
Properties of excitatory and inhibitory synapses (observed using light and electron microscopy), amplitude, frequency, and time constants of excitatory/inhibitory potentials, and intrinsic properties.	—

Secondary

Measure	Time frame
Analysis of protein expression (Western blot analysis, proteomics analyses), analysis of gene expression (RNA analysis), and analysis of chromatin organization (ChIP, ATAC (transposase)-based analysis).	—

Countries

Germany

Contacts

Public ContactAndreas Vlachos

Abteilung für Neuroanatomie Institut für Anatomie und Zellbiologie Albert-Ludwigs-Universität Freiburg

andreas.vlachos@anat.uni-freiburg.de+49 761 203 5056

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026