Microbiom under the pannus in severe obese patients before total hip arthroplasty

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00031531

Enrollment

100

Registered

2023-03-28

Start date

2023-05-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M16.1

Interventions

Group 1: This trial aims to examine the microbiome of the skin within the area of the surgical approach in morbidly obese patients with pannus before total hip arthroplasty. For this, samples of the s

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - primary hip arthritis - total hip arthroplasty planned via direct anterior approach at König-Ludwig-Haus - experimental group: BMI > 35 and abdominal pannus covering the anterior approach - control group: BMI < 25 and no abdominal pannus - informed consent by the patient

Exclusion criteria

Exclusion criteria: - Use of local antibiotics or steroids within the last 7 day - Skin lesions with less than 5 cm distance from the sampling area - Skin deseases within the sampling area - Rash of the skin - Body art with less than 5 cm distance from the sampling area - Infections within the last 4 weeks - Use of systemic antibiotics within the last 4 weeks - Use of systemic steroids within the last 4 weeks - Use of immunosuppressants or immunostimulants within the last 4 weeks - Vaccination within the last 4 weeks

Design outcomes

Primary

Measure	Time frame
Is there a difference in the amount and spectrum of bacteria under the pannus compared to patients without overweight and pannus? For this, the following outcome parameters are examined: 1. Portion of gram-negative bacteria in the cultures. 2. Portion of resistent bacteria in the cultures. 3. Portion of typical pathogens of periprostetic joint infections in the cultures. 4. Number of colony forming units on the contact plates.	—

Measure

Time frame

Is there a difference in the amount and spectrum of bacteria under the pannus compared to patients without overweight and pannus? For this, the following outcome parameters are examined: 1. Portion of gram-negative bacteria in the cultures. 2. Portion of resistent bacteria in the cultures. 3. Portion of typical pathogens of periprostetic joint infections in the cultures. 4. Number of colony forming units on the contact plates.

—

Secondary

Measure	Time frame
a) Which bacteria can be isolated in cases of wound infection? Is there a correlation to the microbiom under the pannus? b) Does the rate of wound complications differ between patients with and without pannus?	—

Countries

Germany

Contacts

Public ContactPhilip Anderson

König-Ludwig-Haus Würzburg

p-anderson.klh@uni-wuerzburg.de+499318033135

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026