Odor perception and acute, reversible irritant effects on nose and eyes.
Conditions
Interventions
Group 1: Preliminary study to determine the maximum exposure concentration at which a statistically or physiologically significant, acute and reversible irritant effect at the nose and/or eyes occurs.
Sponsors
Institut für Prävention und Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung Institut der Ruhr-Universität Bochum (IPA)
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: healthy non-smoking persons
Exclusion criteria
Exclusion criteria: lack of study consent active smoking pregnancy/ breastfeeding severe visual and/or hearing impairment olfactory disorders (e.g. anosmia, hyposmia) problems with the nose, e.g. polyps, sinusitis acute illnesses diseases with chronic use of medication severe other diseases, e.g. kidney, liver or hematopoietic system diseases of the immune system, e.g. rheumatism, scleroderma neurological diseases (e.g. seizure disorders, dizziness) psychiatric diseases (e.g. depression) manifest cardiovascular diseases migraine; thyroid dysfunction; diabetes mellitus; manifest respiratory diseases, bronchial hyperreactivity atopy (pos. prick test or sx1 test) or FeNO > 25 ppb contact allergy (e.g. nickel allergy) or skin diseases (e.g. eczema) smoking or non-smoking for less than 12 months substance abuse lack of ergometry suitability wound adhesion after injuries and operations professional or private regular handling of cyanoacrylates
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Odor perception and acute, reversible irritant effects on nose and eyes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Signs of a subclinical nasal inflammatory reaction. | — |
Countries
Germany
Contacts
Public ContactJürgen Bünger
Institut für Prävention und Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung Institut der Ruhr-Universität Bochum (IPA)
Outcome results
None listed