I51
Conditions
Interventions
Group 1: Study patients will be recruited according to the inclusion and exclusion criteria at hospital admission. Non-invasive sonographic examination and non-invasive bioimpedance measurement will b
Sponsors
Medizinische Hochschule Brandenburg Theodor Fontane
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: adult patients with AKD hospitalised with at least one clinical sign of volume overload (oedema, ascitis, pleural effusion), BNP > 250 pg/ml or NT-proBNP > 1000 pg/ml in routine admission laboratory, written informed consent
Exclusion criteria
Exclusion criteria: Pre-diagnosed liver cirrhosis Child-Pugh C, exclusion by examiner if sonographic image acquisition is impossible due to anatomical conditions, pre-existing dialysis requirement
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is the proportion of patients with improvement in VExUS classification compared to clinical recompensation success (defined as: Weight loss, decrease in NT-pro-BNP, decrease in NYHA classification, bioimpedance measurements). | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of patients with acute kidney injury (AKI) during the inpatient stay depending on their VExUS score as well as changes in biomarker concentrations and bioimpedance measurements depending on the VExUS score. Inter- and intra-rater reliability of different ultrasound examiners within the study protocol. Concordance of diuretic use and recommended medication adjustment at hospital discharge in patients' outpatient medical care. Proportion of patients with MACE during the course of the study (3 months follow-up). | — |
Countries
Germany
Contacts
Public ContactChristian Butter
Medizinische Hochschule Brandenburg Theodor Fontane
Outcome results
None listed