F10
Conditions
Interventions
Group 1: Subjects with mild to moderate Alcohol use Disorder (AUD) with min. 2 and max. 5 of the criteria for AUD.
To assess current life circumstances and to obtain a history of current and past use
Sponsors
Zentralinstitut für Seelische Gesundheit Mannheim
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Diagnosis of mild to moderate alcohol use disorder according to DSM V, i.e., 2-5 criteria met. - Sufficient ability to communicate with investigators, to answer questions in oral and written form - Ability to give fully informed consent ("Fully Informed Consent") - Normal or correctable (with contact lenses) visual impairment.
Exclusion criteria
Exclusion criteria: - severe withdrawal symptoms (CIWA-R > 4). - Alcohol intoxication (breath alcohol concentration > 0.3 ‰) - History of withdrawal complications or severe withdrawal symptomatology. - Axis I disorder according to DSM V (except alcohol dependence and specific Phobia within the past 12 months). - Current substance abuse (THC, amphetamine, opiates, benzodiazepines, barbiturates, and cocaine) - Wearing glasses (without the ability to wear contact lenses) - Traumatic brain injury or injury/surgery to the head - Parkinson's disease or epilepsy as a pre-existing condition
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The study aims to investigate attentional control after acoustic alcohol-associated priming in subjects with mild to moderate Alcohol Use Disorder ("AUD"). ("Alcohol Use Disorder", AUD) by measuring eye movement using advanced eye-tracking techniques. Via pupillary response and subsequent scale-based recording of valence, arousal, and subjective craving for substance use, the effect of acoustic priming can be analyzed, and the objective response can be compared with the subjective response of the subjects. For the study of top-down control on the groups (AUD, control group) at lower and higher utilization, inferences can be made about top-down control based on subjects' reaction times and correctly detected objects. Based on the subjects' pupillary response and scale-based subjective information, we expect increased craving for substance use and decreased top-down control in subjects with alcohol use disorder. The aim of the study is to better characterize the influence of priming with addiction-associated audio stimuli on altered attentional control for specific stimulus characteristics (context, complexity) over time. This should serve a better understanding of addiction development and maintenance in relation to alcohol use, thereby perspective, an improved care of patients (e.g. via the improvement of existing cue-exposure procedures) would be possible. In the long term, this should lead to a reduction in the likelihood of relapse. | — |
Secondary
| Measure | Time frame |
|---|---|
| A better understanding of the influence of dependence-associated acoustic priming on altered attentional directing, which could identify additional relapse factors related to harmful alcohol use. | — |
Countries
Germany
Contacts
Public ContactPatrick Bach
Zentralinstitut für Seelische Gesundheit Mannheim
Outcome results
None listed