Early spontaneous breathing in ARDS

Early spontaneous breathing in ARDS - ESpA

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00031486

Enrollment

Registered

2023-04-20

Start date

2023-03-09

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

J80

Interventions

Group 1: Patients with severe and moderate acute respiratory distress syndrome (ARDS)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: invasively ventilated for >24 hours expected to be invasively ventilated for >24 hours oxygenation index <200mmHg despite adequate PEEP Hamilton C6 respirator used tube ID at least 7mm and with subglottic suction Pes probe for pressure measurement available sedation with isoflurane no effect of relaxation anymore project staff available

Exclusion criteria

Exclusion criteria: patients of minor age patients unable to give informed consent contraindication to spontaneous breathing (f.e. intracranial pressure, chest wall instability)

Design outcomes

Primary

Measure	Time frame
Proportion of pressure supported spontaneous breathing in patients with severe and moderate ARDS during the first 24 hours of invasive ventilation	—

Secondary

Measure	Time frame
1. Description of the spontaneous breathing pattern (respiratory rate, tidal volumes, esophageal pressures), 2. detection of drug dosages (isoflurane and remifentanil) and of the arterial CO2 partial pressure, when spontaneous breathing is starting, 3. identification of factors that facilitate or else impede spontaneous breathing, 4. identify the reasons, why spontaneous breathing cannot be installed/must be interrupted.	—

Measure

Time frame

1. Description of the spontaneous breathing pattern (respiratory rate, tidal volumes, esophageal pressures), 2. detection of drug dosages (isoflurane and remifentanil) and of the arterial CO2 partial pressure, when spontaneous breathing is starting, 3. identification of factors that facilitate or else impede spontaneous breathing, 4. identify the reasons, why spontaneous breathing cannot be installed/must be interrupted.

—

Countries

Germany

Contacts

Public ContactAndreas Meiser

Universitätsklinken des Saarlandes

andreas.meiser@uks.eu06841 16 0

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026