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Synovial CRP analysis to validate periprosthetic joint infections

Synovial CRP analysis to validate periprosthetic joint infections - SCRPA

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00031477
Enrollment
500
Registered
2023-05-30
Start date
2023-10-02
Completion date
Unknown
Last updated
2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

T84.5

Interventions

Sponsors

Klinikum Konstanz, Lehrkrankenhaus der Albert-Ludwigs Universität Freiburg
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Presence of a joint endoprothesis

Exclusion criteria

Exclusion criteria: Non- presence of a joint endoprothesis, incomplete data set

Design outcomes

Primary

MeasureTime frame
Sterile puncture of the affected joint with an inserted endoprosthetic replacement if there is a clinical suspicion of a periprosthetic infection. The aim is to detect increased CRP values in the puncture fluid (synovia), i.e. values > 0.5 mg/l) compared to increased CRP values in the blood serum (values > 5 mg/dl).

Secondary

MeasureTime frame
Evaluation of further puncture data such as puncture volume in ml, macroscopic aspect (punctate color), cell count, granulocyte count, presence of crystals; Laboratory results of the blood test of CRP and leukocytes, microbiological culture results (if positive, which germ), pathological results according to Krenn (stage I-IV), number of open biopsies after puncture, number of prosthesis infections requiring revision.

Countries

Germany

Contacts

Public ContactMirjam Neumann-Langen

Klinikum Konstanz, Lehrkrankenhaus der Albert-Ludwigs Universität Freiburg

mirjam.langen@glkn.de+49 7531 801 1219

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026