Resistance of oral microorganisms against chlorhexidine and cross-resistance against antibiotics

Resistance of oral microorganisms against chlorhexidine and cross-resistance against antibiotics - ROMaCHX

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00031475

Enrollment

Registered

2023-03-16

Start date

2020-06-01

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Samples of oral supragingival biofilm and saliva will be taken from patients suffering from periodontitis.

Interventions

Group 1: 20 patients The patients applied ca. 2 ml of mouthwash including 0.2% chlorhexidine (0.2%, free of alcohol, provided by the pharmacy of the University Hospital Freiburg) two times daily for

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Sufficient knowledge of German Written informed consent Indication for regenerative or plastic periodontal surgery with the indication for post operative CHX rinsing

Exclusion criteria

Exclusion criteria: Severe general illnesses Intake of drugs influencing the salivation rate Pregnancy or breast feeding Active systematic periodontal therapy within the last 2 years Use of antibiotics or antifungals within the last 3 months Allergies against CHX or components of the mouthrinse

Design outcomes

Primary

Measure	Time frame
Bevor teatment (Baseline). Directly after the four weeks of treatment and four weeks after stopping treatment	—

Secondary

Measure	Time frame
statistically evaluated results from primary outcome	—

Countries

Germany

Contacts

Public ContactAli Al-Ahmad

Universitätsklinikum der Albert-Ludwigs-Universität Freiburg, Klinik für Zahnerhaltungskund und Parodontologie

ali.al-ahmad@uniklinik-freiburg.de+49 761 27048940

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 11, 2026