Validation of optical rhinometry and nasal nitric oxide measurement for clinical use in allergic and non-allergic patients based on acoustic rhinometry and active anterior rhinomanometry

Validation of optical rhinometry and nasal nitric oxide measurement for clinical use in allergic and non-allergic patients based on acoustic rhinometry and active anterior rhinomanometry - VoRnNO Study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00031457

Enrollment

160

Registered

2023-03-10

Start date

2023-02-06

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

J30.4

Interventions

Group 1: Control group without allergy Acute symptom and sensation intensity questionnaires and characterization of study participants. Aptitude test about 3h : ENT examination, sinus ultrasound, b

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: No allergies (negative prick test, negative medical history, sX1 and IgE normal) Birch pollen allergy (matching seasonal complaints, prick test positive for early bloomers and blood serum birch pollen sensitization detectable) House dust mite allergy (suitable seasonal complaints, prick test and proof of sensitization in serum to Derm pter. and/or farinae detectable)

Exclusion criteria

Exclusion criteria: active smoking High blood pressure & medication with ACE inhibitors and/or beta blockers pregnancy/breastfeeding known severe reactions to histamine history of anaphylactic reaction (allergic shock) systemic cortisone medication < 3 weeks medication with antihistamines < 3 weeks Polyposis nasi infection less than four weeks ago local allergic rhinopathy nonspecific nasal hyperreactivity

Design outcomes

Primary

Measure	Time frame
The aim of the present study is to validate both optical rhinometry and nasal nitric oxide measurement. Since optical rhinometry measures continuously, the hypothesis is that allergic reactions of the nose can be determined earlier and possibly more sensitively than before. With respect to nasal NO, the goal is to find a defined measurement change that defines a positive nasal provocation, similar to FeNO.	—

Measure

Time frame

The aim of the present study is to validate both optical rhinometry and nasal nitric oxide measurement. Since optical rhinometry measures continuously, the hypothesis is that allergic reactions of the nose can be determined earlier and possibly more sensitively than before. With respect to nasal NO, the goal is to find a defined measurement change that defines a positive nasal provocation, similar to FeNO.

—

Secondary

Measure	Time frame
Secondary endpoint is to establish, if possible, a cut-off value for a positive (allergic) nasal response for optical rhinometry.	—

Countries

Germany

Contacts

Public ContactKerstin Belting

DGUV, Institut für Prävention und Arbeitsmedizin Bochum

kerstin.belting@dguv.de+30130014122

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026