Cancer, general
Conditions
Interventions
Group 1: Healthy individuals undergo blood draws once over 24 hours at 8am, 11am, 2pm, 5pm, 8pm, midnight, 6am and again 8am.
Group 2: Healthy individuals undergo blood draws once over 24 hours at 8am
Sponsors
Deutsches Krebsforschungszentrum Heidelberg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Healthy volunteers: no further Cancer patients: - systemic tumor disease currently requiring treatment (systemic: leukemia, lymphoma (stage >I), myelodysplastic syndrome/myeloproliferative neoplasia, metastasized solid tumor) - scheduled inpatient stay of at least 3 days
Exclusion criteria
Exclusion criteria: Healthy individuals: - any condition requiring medication currently or less than one month ago - regular intake of medication, including oral contraceptives (excluding vitamins) - currently or less than two months ago smoking, alcohol or substance abuse - anemia (hemoglobin peripheral blood, determined by patient history, <10g/dl (female) or <11g/dl (male) within the last year) - symptomatic hypotonia (blood pressure regularly or several times below 100/60 mmHg) - collapse or syncope with orthostasia several times in patient history Cancer patients: - severe anemia (hemoglobin in the last month at least once below 7g/dl, several times below 8g/dl or currently (within 72 hours before start of study) below 9g/dl - hypotonia (blood pressure in the last month regularly or several times below 100/60mmHg or currently 110/60mmHg) - collapse or syncope with orthostasia several times in patient history - IV line infection currently or less than one month ago - intake of oral contraceptives
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Circadian assessment of quantity, size and proteomic content of plasma-derived extracellular vesicles. | — |
Countries
Germany
Contacts
Public ContactKatharina Clemm von Hohenberg
Deutsches Krebsforschungszentrum Heidelberg
Outcome results
None listed