Training study to optimize training adaptions of endurance training through increasing intensity

Conditions

primary prevention

Tiffany Wences Chirino, Frederike Adammek, Sergen Belen, Matteo Winker, Sebastian Proschinger et al. (18 authors)

Acta Physiologica2026-01-28

10.1111/apha.70166

Persons With Multiple Sclerosis Reveal Distinct Kynurenine Pathway Metabolite Patterns

Marie Kupjetz, Martin Langeskov‐Christensen, Morten Riemenschneider, Stefan Inerle, Uwe Ligges et al. (20 authors)

Neurology Neuroimmunology & Neuroinflammation2025-09-18

10.1212/nxi.0000000000200461

Effects on cardiorespiratory fitness of moderate-intensity training vs. energy-matched training with increasing intensity

Marcel Reuter, Friederike Rosenberger, Andreas Barz, Andreas Venhorst, Laura Blanz et al. (7 authors)

Frontiers in Sports and Active Living2024-01-048 citations

10.3389/fspor.2023.1298877

Does Higher Intensity Increase the Rate of Responders to Endurance Training When Total Energy Expenditure Remains Constant? A Randomized Controlled Trial.

Reuter M, Rosenberger F, Barz A, Venhorst A, Blanz L, Hecksteden A, Meyer T.

2023-05-209 citations

10.1186/s40798-023-00579-3

Interventions

Group 1: 16 healthy, untrained adults trained for 26 weeks with moderate intensity (3 days per week, 50 minutes per session, training intensity 55HRreserve) Group 2: 16 healthy, untrained adults train

Eligibility

Sex/Gender

All

Age

30 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1) healthy 2) nonsmokers 3) training status, within the last 6 months, no regular endurance training and no other training-effective activity > 1 h/week; strength training < 2 units/week 4) never competitive sports 5) VO2max Männer < 50 ml * kg-1*min-1; Frauen < 45 ml * kg-1*min-1

Exclusion criteria

Exclusion criteria: 1) BMI > 30 kg•m-2 2) resting blood pressure (RRrest) = 160/100 mmHg) 3) total cholesterol = 300 mg•dl-1 4) maximum oxygen uptake (V?O2max) > 50 ml•kg-1•min-1 for men; > 45 ml•kg-1•min-1 for women 5) iron deficiency (Ferritin = 34 ng•ml-1) 6) thyroid dysfunction (TSH = 0.34 mU•l-1; = 4.0 ng•ml-1) 7) medications with potential influence on target parameters (e.g. beta-blockers) and pregnancy 8) Internal or orthopedic diseases for which maximum exertion or regular running training is contraindicated.

Design outcomes

Primary

Measure	Time frame
Data were recorded three times at baseline, after 10 weeks, after 18 weeks and after 26 weeks of training. Cardiorespiratory fitness was measured by a) maximum oxygen uptake (VO2max), b) maximum running speed, c) running economy, d) submaximal heart rate, e) lactate kinetics. Measures were performed three times at baseline, after 10 weeks, 18 weeks and after 26 weeks of training. Testing procedures Three baseline exercise tests were performed for habituation and to assess day-to-day variability of V?O2max. At basline all participants underwent a medical examination, blood sampling, resting and exercise electrocardiogram (ECG), and maximal cardiorespiratory exercise testing on a treadmill (type ELG 70, Woodway GmbH, Weil am Rhein, Germany). Before exercise testing, height and body weight were measured. Body fat percentage was assessed by a 10-site skinfold method with a Harpenden caliper. Resting heart rate (HRrest) and resting blood pressure (RRrest) were assessed in supine position after a ten minute resting period at the right and left arm. Gas exchange measurements were conducted continuously using a breath-by-breath system (MetaLyzer® 3B, Cortex Biophysik GmbH, Leipzig, Germany). Lactate samples were taken at rest, during each break between GXT stages, and during the post-exercise period (1st, 3rd, and 5th min) from the hyperaemised earlobe. An enzymatic-amperometric method was used to analyse the samples (Super GL, Rolf Greiner Biochemica, Flacht, Germany).	—

Measure

Time frame

Data were recorded three times at baseline, after 10 weeks, after 18 weeks and after 26 weeks of training. Cardiorespiratory fitness was measured by a) maximum oxygen uptake (VO2max), b) maximum running speed, c) running economy, d) submaximal heart rate, e) lactate kinetics. Measures were performed three times at baseline, after 10 weeks, 18 weeks and after 26 weeks of training. Testing procedures Three baseline exercise tests were performed for habituation and to assess day-to-day variability of V?O2max. At basline all participants underwent a medical examination, blood sampling, resting and exercise electrocardiogram (ECG), and maximal cardiorespiratory exercise testing on a treadmill (type ELG 70, Woodway GmbH, Weil am Rhein, Germany). Before exercise testing, height and body weight were measured. Body fat percentage was assessed by a 10-site skinfold method with a Harpenden caliper. Resting heart rate (HRrest) and resting blood pressure (RRrest) were assessed in supine position after a ten minute resting period at the right and left arm. Gas exchange measurements were conducted continuously using a breath-by-breath system (MetaLyzer® 3B, Cortex Biophysik GmbH, Leipzig, Germany). Lactate samples were taken at rest, during each break between GXT stages, and during the post-exercise period (1st, 3rd, and 5th min) from the hyperaemised earlobe. An enzymatic-amperometric method was used to analyse the samples (Super GL, Rolf Greiner Biochemica, Flacht, Germany).

—

Secondary

Measure	Time frame
Health related outcomes were measured by A) resting heart rate B) resting blood pressure C) body composition D) bloodmarkers (e.g. cholesterol). A, B, C, D were measured in both groups at baseline, after 10 weeks, 18 weeks and 26 weeks.	—

Countries

Germany

Contacts

Public ContactTim Meyer

Institut für Sport- und Präventivmedizin Universität des Saarlandes

tim.meyer@mx.uni-saarland.de+49 681-302 70400

Outcome results

None listed