Characterisation of blood cell aggregates in sepsis using digital holographic microscopy

Characterisation of blood cell aggregates in sepsis using digital holographic microscopy - ARTEMIS

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00031443

Enrollment

100

Registered

2023-05-02

Start date

2023-01-09

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

A41.9

Interventions

Group 1: positive qSOFA score: Assessment of clinical, laborchemical and imaging data from the medical chart, assessment of blood cells and aggregates using digital holographic microscopy (DHM) and as

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: positive qSOFA (minimum two of three criteria: respiratory rate = 22/min, GCS<15, systolic blood pressure = 100 mmHg) OR healthy individuals

Exclusion criteria

Exclusion criteria: lack of consent

Design outcomes

Primary

Measure	Time frame
- blood cell aggregates (assessed using DHM within 48h from positive qSOFA (t0), on day 2-4 (t1) and on day 5-7 (t2) if still hospitalized, once before discharge (tf) and in ICU patients every 3-4 days) - antigen- and cell-specific cytokine release	—

Secondary

Measure	Time frame
- cell granularity - immune status - mortality - course of procalcitonin, interleukin-6, lactate - maximum dose of catecholamines - duration of catecholamine therapy - length of hospital stay - rate of secondary infection (need for second antiinfective treatment of at least three days or second documented infection during hospital stay) - ICU admission - SOFA score	—

Countries

Germany

Contacts

Public ContactSebastian Rasch

Klinikum rechts der Isar

sebastian.rasch@mri.tum.de+4941409352

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 11, 2026