Cognitive development of children with complex congenital heart defects following palliative surgery

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00031384

Enrollment

Registered

2023-03-27

Start date

2023-02-28

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Q20-Q28

Interventions

Group 1: Congenital heart defects are among the most common organ malformations in newborns. Advances in the diagnosis and therapy of these malformations have significantly improved the survival of th

Eligibility

Sex/Gender

All

Age

6 Years to 16 Years

Inclusion criteria

Inclusion criteria: 1. Congenital heart defect (univentricular heart, transposition of the great arteries, tetralogy of Fallot, aortic isthmus stenosis, atrial septal defect) 2. Consent of the patient and/or legal guardian

Exclusion criteria

Exclusion criteria: 1. Syndromic disease with impairment of cognitive development (trisomy 21, microdeletion syndrome (22q11)) 2. Missing onsent of the patient and/or legal guardian

Design outcomes

Primary

Measure	Time frame
1. Intelligence quotient (IQ) using Wechsler Intelligence Scale for Children – Fifth Edition (WISC-V) 2. Evaluation of microRNA profiles after cardiac surgery for complex congenital heart defects (UVH, dTGA, TOF)	—

Secondary

Measure	Time frame
Index values (speech comprehension, visual-spatial skills, fluid reasoning, working memory, processing speed) Head circumference Brain volume Scholastic Achievement Folic acid level	—

Countries

Germany

Contacts

Public ContactHashim Abdul-Khaliq

Universitätsklinikum des Saarlandes, Klinik für Pädiatrische Kardiologie

hashim.abdul-khaliq@uks.eu+49 6841 16 28306

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026