Stress/damage and repair mechanisms of neonatal monocytes at different iron exposure compared to adult monocytes

Stress/damage and repair mechanisms of neonatal monocytes at different iron exposure compared to adult monocytes - NEOMOS

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00031364

Enrollment

120

Registered

2023-03-03

Start date

2023-03-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Susceptibility of newborns to infections

Interventions

Group 1: Our study is designed to increase our understanding of the pathophysiological processes and interrelationships between iron metabolism and immune cells. Hypothesis: Neonatal monocytes differ

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Mothers: - Written informed consent by the study participant - Age = 18 years Neonates: - Informed consent by legal representative(s) Healthy subjects: - Written informed consent by the study participant - Age = 18 years

Exclusion criteria

Exclusion criteria: - Inclusion of the mother in an interventional study - Infectious viral disease (HBV, HCV, HIV, COVID-19) or unknown COVID-19 status in the mother - Iatrogenic immunosuppression of the mother

Design outcomes

Secondary

Measure	Time frame
Immune cell function in functional assays, iron-regulated gene profile, routine clinical and laboratory chemistry parameters, further endpoints will depend on the results of initial experiments	—

Primary

Measure	Time frame
in vitro Immune response of monocytes after cell incubation with immunostimulatory substances under a wide range of iron environmental conditions	—

Countries

Germany

Contacts

Public ContactDania Fischer

Universitätsklinikum Heidelberg

dania.fischer@med.uni-heidelberg.de+49 6221-56-36166

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026