Individualized 3D planned hip reconstruction in cerebral palsy

Individualized 3D planned hip reconstruction in cerebral palsy - HipRecCP

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00031356

Enrollment

Registered

2023-07-14

Start date

2023-07-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G80

Interventions

Group 1: Conventional hip reconstruction (Control group) The cut and correction are determined by eye measurement, as has been standard up to now. A computed tomography (CT) scan and clinical data ar

Eligibility

Sex/Gender

All

Age

4 Years to No maximum

Inclusion criteria

Inclusion criteria: - Patients with bilateral cerebral palsy, GMFCS III to V - Minimum age of 4 years and open triradiate cartilage - MI = 40% of at least one hip - Indication for surgery on both hips - CT with possible 3D reconstruction - Signed ethical consent

Exclusion criteria

Exclusion criteria: - MI = 100% - Relevant lumbar scoliosis (>20°) associated with pelvic obliquity - Limited compliance for examinations - Claustrophobia in CT - Withdrawal of study

Design outcomes

Primary

Measure	Time frame
Research question 1: For the primary research question, the three-directional acetabular index (3-DAI) is used as a primary parameter. The purpose of the primary research part is to determine in which intervention group there is a greater improvement in the acetabular coverage. To express this improvement, the difference of the 3-DAI at E0 (before surgery) to 3-DAI at E2 (6 weeks after surgery) is calculated separately in both groups. The differences of both groups are compared. The actual correction is represented by the difference of 3-DAI at E0 to 3-DAI E1 (immediately after surgery). To analyze the correction accuracy, this difference of the CAOS group is compared to that of the control group. Furthermore, the loss of correction is indicated by the difference of 3-DAI at E1 and 3-DAI at E2. The differences of both groups are compared to detect a possible loss of correction in one method. In addition, it is checked which group (CAOS or control group) has a more accurate correction. For this purpose, the 3-DAI of the cerebral palsy group at E2 is compared to the 3-DAI calculated as the correction target in the CAOS planning.	—

Measure

Time frame

Research question 1: For the primary research question, the three-directional acetabular index (3-DAI) is used as a primary parameter. The purpose of the primary research part is to determine in which intervention group there is a greater improvement in the acetabular coverage. To express this improvement, the difference of the 3-DAI at E0 (before surgery) to 3-DAI at E2 (6 weeks after surgery) is calculated separately in both groups. The differences of both groups are compared. The actual correction is represented by the difference of 3-DAI at E0 to 3-DAI E1 (immediately after surgery). To analyze the correction accuracy, this difference of the CAOS group is compared to that of the control group. Furthermore, the loss of correction is indicated by the difference of 3-DAI at E1 and 3-DAI at E2. The differences of both groups are compared to detect a possible loss of correction in one method. In addition, it is checked which group (CAOS or control group) has a more accurate correction. For this purpose, the 3-DAI of the cerebral palsy group at E2 is compared to the 3-DAI calculated as the correction target in the CAOS planning.

—

Secondary

Measure	Time frame
Research question 2: In the retrospective part, an age-matched typically-developing reference group is generated. The aim is to detect the acetabular deficit and dislocation direction in children with cerebral palsy (CP). For this purpose, different parameters (head-shaft-angle (HSA), center-edge angle (CEA), CCD, AI, MI, 3-DAI and AV) are used. These are described descriptively. The values of the typically-developing group are compared with those of the CP group. Research question 3: As the main purpose of the retrospective part, an algorithm is developed to describe the acetabular coverage and dislocation directions three-dimensionally as a basis for the development of a 3D-head coverage-index (3D-HCI) relevant for outcome measurement. To evaluate this new index, it will be correlated with the already existing parameters MI, AI, 3-DAI and AV. The correlation will be analyzed separately in both groups. The aim is to use the 3D-HCI as a new 3D-parameter to express the acetabular coverage and therefore it will be taken as a secondary parameter in the prospective study.	—

Measure

Time frame

Research question 2: In the retrospective part, an age-matched typically-developing reference group is generated. The aim is to detect the acetabular deficit and dislocation direction in children with cerebral palsy (CP). For this purpose, different parameters (head-shaft-angle (HSA), center-edge angle (CEA), CCD, AI, MI, 3-DAI and AV) are used. These are described descriptively. The values of the typically-developing group are compared with those of the CP group. Research question 3: As the main purpose of the retrospective part, an algorithm is developed to describe the acetabular coverage and dislocation directions three-dimensionally as a basis for the development of a 3D-head coverage-index (3D-HCI) relevant for outcome measurement. To evaluate this new index, it will be correlated with the already existing parameters MI, AI, 3-DAI and AV. The correlation will be analyzed separately in both groups. The aim is to use the 3D-HCI as a new 3D-parameter to express the acetabular coverage and therefore it will be taken as a secondary parameter in the prospective study.

—

Countries

Switzerland

Contacts

Public ContactThomas Dreher

Universitäts-Kinderspital Zürich

thomas.dreher@kispi.uzh.ch+41 44 266 75 35

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Apr 1, 2026