Circadian dependence of habituation/extinction learning in exposure therapy in patients with anxiety spectrum disorders

Circadian dependence of habituation/extinction learning in exposure therapy in patients with anxiety spectrum disorders - EMA

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00031341

Enrollment

180

Registered

2023-03-06

Start date

2023-03-13

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F40 F41 F42 F43.1

Interventions

Group 1: Exposure sessions 1 and 2 starting at 08:00 h (Duration of at least 90 minutes, in attendence of a trained therapist, focussing on the same stimulus of at least 50% intensity according to the

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Anxiety disorder, obsessive-compulsive disorder, or post-traumatic stress disorder Clinical indication for exposure therapy

Exclusion criteria

Exclusion criteria: Psychotic disorder, organic psychiatric disorder, current drug abuse or dependency, acute suicidality, pregnancy, epilepsy, clinically relevant heart or lung disease

Design outcomes

Primary

Measure	Time frame
Within-session habituation (1st exposure session) as per Subjective Units of Distress (100 mm visual analogue scale) and Between-session habituation (exposure sessions 1 and 2) as per Subjective Units of Distress (100 mm visual analogue scale)	—

Secondary

Measure	Time frame
Salivary cortisol and alpha-amylase during the first two exposure sessions	—

Countries

Germany

Contacts

Public ContactMichael Kellner

Klinikum rechts der Isar der Technischen Universität München

michael.kellner@mri.tum.de+49 89 4140 4227

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 11, 2026