Adjustment of Positive End-Expiratory Pressure according to Body Mass Index during Mechanical Ventilation for Routine General Anesthesia A Randomized Controlled Trial

Adjustment of Positive End-Expiratory Pressure according to Body Mass Index during Mechanical Ventilation for Routine General Anesthesia A Randomized Controlled Trial - BODYVENT

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00031336

Enrollment

Registered

2023-02-21

Start date

2023-02-28

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intraoperative Ventilation Postoperative pulmonary complications

Interventions

Group 1: Adjustment of Positive End-Expiratory Pressure according to Body Mass Index during Mechanical Ventilation for Routine General Anesthesia Group 2: Positive end-expiratory pressure of 5 mbar d

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Planned surgery under general anaesthesia with endotracheal intubation. Expected duration of surgery = 2h Written informed consent

Exclusion criteria

Exclusion criteria: - Mask anaesthesia or laryngeal mask - Pregnant women - Laparoscopic operations - Thoracic surgery - Operations with cardiopulmonary bypass - Operations in > 10° Trendelenburg/Antitrendelenburg position - Acute cardiac/pulmonary decompensation - Acute respiratory distress syndrome (ARDS) according to Berlin definition - Known pulmonary fibrosis - Pneumonia (current or within the last 30 days) - Chronic obstructive pulmonary disease severity GOLD IV - BMI > 60 - Lack of capacity to consent

Design outcomes

Primary

Measure	Time frame
Driving Pressure (?P), defined as difference between airway plateau pressure and positive end-expiratory pressure during general anesthesia	—

Secondary

Measure	Time frame
Change in lung aeration score between the time points before surgery and after arrival in the recovery room (determined by lung ultrasound) SpO2 after arrival in the recovery room (without oxygen insufflation) Number of patients with indication for oxygen insufflation (to maintain SpO2 = 90%). Mechanical ventilation performance (elastic-dynamic, tidal and total). Compliance of the respiratory system Intraoperative fluid requirements Average intraoperative vasopressor requirements (µg/kg/min). Number of hypotension events (MAD 1 min) Time-weighted average of hypotensions Number of intraoperative alveolar recruitment manoeuvres (to be performed only if SpO2 60%). Postoperative pulmonary complications	—

Measure

Time frame

Change in lung aeration score between the time points before surgery and after arrival in the recovery room (determined by lung ultrasound) SpO2 after arrival in the recovery room (without oxygen insufflation) Number of patients with indication for oxygen insufflation (to maintain SpO2 = 90%). Mechanical ventilation performance (elastic-dynamic, tidal and total). Compliance of the respiratory system Intraoperative fluid requirements Average intraoperative vasopressor requirements (µg/kg/min). Number of hypotension events (MAD 1 min) Time-weighted average of hypotensions Number of intraoperative alveolar recruitment manoeuvres (to be performed only if SpO2 60%). Postoperative pulmonary complications

—

Countries

Germany

Contacts

Public ContactTobias Becher

Universitätsklinikum Schleswig-Holstein

tobias.becher@uksh.de043150020980

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 6, 2026