Characterization of OCUlomotor responses in Deep Brain Stimulation of the VENtral mesencephalic tegmentum

Characterization of OCUlomotor responses in Deep Brain Stimulation of the VENtral mesencephalic tegmentum - OCUVEN

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00031266

Enrollment

Registered

2023-02-13

Start date

2023-06-20

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F42

Interventions

Group 1: Patients implanted with a deep brain stimulation (DBS) system for the treatment of treatment-resistant obsessive-compulsive disorder (TROCD) or treatment-resistant depression (TRD). In these

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients who are in a stable psychiatric condition and transient change of stimulation is feasible 2. Patient gives written informed consent for participation 3. Patients are willing to and can tolerate transient mild stimulation induced double vision (not painful) 4. Compliance to participate in the study

Exclusion criteria

Exclusion criteria: 1. Congenital strabismus 2. Any acquired eye movement disorder. 3. Orbital diseases 4. Any previous ocular surgery 5. Visual acuity in any eye < 0.3 6. High myopia 7. Acute eye condition (glaucome, infection) 8. Patient is incapable to follow and perform the task instructions 9. No written consent available

Design outcomes

Primary

Measure	Time frame
Objectives (What): - To achieve a detailed characterization of oculomotor responses in Deep Brain Stimulation of the ventral mesencephalic tegmentum - to achieve a rigid anatomical description of stimulation effects with respect to a stochastic brain space (MNI, Montreal Neurological Institute Brain) - including high resolution MRI and DTI (tractography) and - analysis of the oculomotor response to DBS. - to understand if complex (cyclovertical) oculomotor effects (17) can be elicited and how they are related to local anatomy and stimulation settings in TRD and TROCD. When: In a 4-hour out-patient type test session How: Different stimulation settings are activated and accompanied by a detailed eye examination. During the session, eye alignment is recorded during different tested stimulation settings in the three spatial planes (horizontal / vertical / torsional) using a tangent screen and binocular red-green glasses ("Harms wall" examination). The target variables are the deviations from the respective neutral position in the solid angle. The deviations in space as well as the rotation are evaluated together with the required current strength (amplitude) as well as the position of the electrode contact.	—

Measure

Time frame

Objectives (What): - To achieve a detailed characterization of oculomotor responses in Deep Brain Stimulation of the ventral mesencephalic tegmentum - to achieve a rigid anatomical description of stimulation effects with respect to a stochastic brain space (MNI, Montreal Neurological Institute Brain) - including high resolution MRI and DTI (tractography) and - analysis of the oculomotor response to DBS. - to understand if complex (cyclovertical) oculomotor effects (17) can be elicited and how they are related to local anatomy and stimulation settings in TRD and TROCD. When: In a 4-hour out-patient type test session How: Different stimulation settings are activated and accompanied by a detailed eye examination. During the session, eye alignment is recorded during different tested stimulation settings in the three spatial planes (horizontal / vertical / torsional) using a tangent screen and binocular red-green glasses ("Harms wall" examination). The target variables are the deviations from the respective neutral position in the solid angle. The deviations in space as well as the rotation are evaluated together with the required current strength (amplitude) as well as the position of the electrode contact.

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Countries

Germany

Contacts

Public ContactVolker A. Coenen

Universitätsklinikum Freiburg

volker.coenen@uniklinik-freiburg.de+49 761 270-50630

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026