Nutritional intervention to reduce the omega-6/omega-3 fatty acid ratio

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00031261

Enrollment

Registered

2024-01-19

Start date

2024-01-05

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy individuals with an interest in brain health/dementia prevention.

Interventions

Group 1: Intervention group: Dietary counselling to reduce omega-6-containing foods and increase omega-3-containing foods (1x, 60-90 min)

then, for 10 weeks, replacement of oils in cooking with rapeseed oil and linseed oil (provided as part of the study) and intake of fish oil capsules (120mg docosahexaenoic acid (DHA) and 180mg eicosap

Eligibility

Sex/Gender

All

Age

50 Years to No maximum

Inclusion criteria

Inclusion criteria: -Age at least 50 years -Nutrition according to a "Western Diet" -Willingness to take fish oil capsules

Exclusion criteria

Exclusion criteria: - Diagnosis of dementia - Practising an energy-reduced diet (diet) - Diseases which, according to medical judgement, have an effect on the bioavailability and metabolism of polyunsaturated fatty acids (e.g. gastrointestinal diseases, liver diseases) - A vegetarian/vegan diet, other alternative diets with significantly altered/restricted food choices

Design outcomes

Primary

Measure	Time frame
Reduction in the omega-6/omega-3 fatty acid ratio of the intervention group before and after the intervention compared with the control group, measured in blood (arachidonic acid ARA/eicosapentaenoic acid EPA). Comparison is based on blood sampling before the start of the nutritional intervention (T0) and after completion (T10).	—

Secondary

Measure	Time frame
Exploratory data will be collected on: Change in diet/intake of omega-6/omega-3 fatty acids by Food Frequency Questionnaire and 24h Food Recall Questionnaire (T0,T2,T4,T6;T8,T10); Cognitive performance (T0,T10) using neuropsychological testbatterie consisting of CERAD+ and additional tests; genome-wide methylation data (blood sampling at T0, T10); inflammation markers (blood sampling at T0, T10); possible changes in lifestyle and well-being between T0 and T10	—

Measure

Time frame

Exploratory data will be collected on: Change in diet/intake of omega-6/omega-3 fatty acids by Food Frequency Questionnaire and 24h Food Recall Questionnaire (T0,T2,T4,T6;T8,T10); Cognitive performance (T0,T10) using neuropsychological testbatterie consisting of CERAD+ and additional tests; genome-wide methylation data (blood sampling at T0, T10); inflammation markers (blood sampling at T0, T10); possible changes in lifestyle and well-being between T0 and T10

—

Countries

Germany

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026