Influence of different resistance training programs on morphological adaptations of the anterior cruciate ligament and the M. quadriceps femoris in males and females

Influence of different resistance training programs on morphological adaptations of the anterior cruciate ligament and the M. quadriceps femoris in males and females - VKB-MUV

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00031249

Enrollment

Registered

2023-02-17

Start date

2023-03-20

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prevention of anterior cruciate ligament injuries

Interventions

Group 1: High-load resistance training (HLRT) = high mechanical load per repetition and training session with a low number of repetitions Group 2: Blood flow restriction training in combination with l

Eligibility

Sex/Gender

All

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: (1) Healthy female and male participants (2) Untrained (no strength training on regular basis during the last year)

Exclusion criteria

Exclusion criteria: (1) Metal-containing or electrically conductive objects in the body (e.g., spiral, solid braces, clips, vessel clips, pacemakers or joint prostheses). (2) Injuries of the anterior cruciate ligament or other ligaments, menisci, cartilage of the knee joint (3) Regular smokers (4) Cachexia or obesity (BMI 30 kg/m²). (5) Active or suspected infection (6) Severe heart failure and COPD or a high risk of thrombosis (7) Acute spinal disease (e.g., lumboischialgia, disc prolapse, spinal stenosis). (8) Severe joint, muscular or systemic diseases (9) Neurological diseases affecting cognition (10) Manifest tumour or other severe chronical diseases

Design outcomes

Primary

Measure	Time frame
Primary outcome of this study is the alteration of the anterior cruciate ligament volume. It is measured before and after the intervention period (16 weeks) using magnetic resonance imaging (MRI).	—

Secondary

Measure	Time frame
Additional outcomes measured before and after the intervention period are: muscle volume (MRI) and maximal voluntary muscle strength of the thigh muscles (by means of dynamometry) as well as the maximal muscle activity during this maximum voluntary contraction (by means of electromyography).	—

Countries

Germany

Contacts

Public ContactJudith Osterloh

Forschungslabor für Biomechanik und Implantattechnologie, Orthopädische Klinik und Poliklinik, Universitätsmedizin Rostock

judith.osterloh@med.uni-rostock.de+49 381 494 9334

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026