Detection of Calcitonin Gene-related Peptide (CGRP) in perilymph of patients with Menière’s Disease

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00031208

Enrollment

Registered

2023-03-02

Start date

2022-08-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

H81.0

Interventions

Group 1: Concentration of CGRP in the perilymph with ELISA in patients with Menière's Disease and indication for cochlear implantation at timepoint of cochlear implantation

history of vertigo

history of cephalgia

questionnaire Dizziness Handicap Inventory Group 2: Concentration of CGRP in the perilymph with ELISA in patients without vestibular disease and indication for cochlear implantation

questionnaire Dizziness Handicap Inventory

Eligibility

Sex/Gender

All

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: study group: Menière's Disease (according to the current diagnostic criteria) and indication for cochlear implantation; control group: indication for cochlear implantation

Exclusion criteria

Exclusion criteria: other vestibular disease, migraines, contact lenses on the day of testing, ophthalmologic disease (other than corrected visual disorder), severe internal, neurologic or psychiatric disease, known hypertension, on the day of testing: ingested antihypertensive medication or 2x detection of hypertension (> 140/90 mmHG), ingestion of painkillers within the last 48 hrs, ingestion of alcohol/nicotine/caffeinated drinks with in the last 12 hrs, pregancy or nursing period

Design outcomes

Primary

Measure	Time frame
Concentration of CGRP in the perilymph measured with ELISA at timepoint of cochlear implantation	—

Secondary

Measure	Time frame
Correlation of CGRP concentration in blood and lacrimal fluid	—

Countries

Germany

Contacts

Public ContactJennifer Spiegel

LMU Klinik, Universitätsklinikum der Ludwig Maximilians Universität München

jennifer.spiegel@med.uni-muenchen.de+498944000

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026