Relationship between Post-Stroke Psychopathology, Laterality of Lesion Site and Psychological Flexibility: The PSYFLEX Trial

Relationship between Post-Stroke Psychopathology, Laterality of Lesion Site and Psychological Flexibility: The PSYFLEX Trial - PSYFLEX

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00031204

Enrollment

Registered

2023-02-21

Start date

2023-03-06

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F06.3 F06.4

Interventions

Group 1: One-group cross-sectional research design to determine the statistical relationship between Post-Stroke Psychopathology, Laterality of Lesion Site and Psychological Flexibility. Participants

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: (1) first-time cerebrovascular accident; (2) lesion either in the right or in the left hemisphere; (3) stage between two weeks and six months post-stroke at the time of testing.

Exclusion criteria

Exclusion criteria: (1) lesion extending to both hemispheres, brainstem or cerebellum; (2) severe deficits in speech comprehension, as determined by less than 10 correct reactions on the subscale “Request for eye movement and head movement” from the Aachener Aphasie-Bedside Test (Biniek et al., 1992); (3) serious non-verbal cognitive deficits, as determined by performance on the Corsi-Block-Tapping Task more than two standard deviations below the average total score (Kessels et al., 2000); (4) premorbid diagnosis of recurrent affective disorder; (5) severe comorbid and chronic somatic disease, such as Morbus Crohn or Colitis ulcerosa.

Design outcomes

Primary

Measure	Time frame
Here, we aimed to explore two potential sources of post-stroke psychopathology: left- or right-hemispheric localization of the acquired brain damage, and psychological flexibility as an increasingly recognized factor in mental health research. -Depressive symptomatology: Simplified Beck Depression Inventory; Hospital Anxiety and Depression Scale, 7-Item Hamilton Depression Rating Scale, ICD-10 Symptom-Rating -Anxiety symptomatology: Hospital Anxiety and Depression Scale -Symptoms of obsessive-compulsive disorder, somatoform disorder, eating disorder, general mental distress: ICD-10 Symptom-Rating -Laterality of lesion site obtained from medical records	—

Measure

Time frame

Here, we aimed to explore two potential sources of post-stroke psychopathology: left- or right-hemispheric localization of the acquired brain damage, and psychological flexibility as an increasingly recognized factor in mental health research. -Depressive symptomatology: Simplified Beck Depression Inventory; Hospital Anxiety and Depression Scale, 7-Item Hamilton Depression Rating Scale, ICD-10 Symptom-Rating -Anxiety symptomatology: Hospital Anxiety and Depression Scale -Symptoms of obsessive-compulsive disorder, somatoform disorder, eating disorder, general mental distress: ICD-10 Symptom-Rating -Laterality of lesion site obtained from medical records

—

Secondary

Measure	Time frame
Descriptive variables: (1) age, (2) sex, (3) years of education, (4) Number of secondary diagnoses (5) diagnosis of mild aphasia (6) current psychopharmacotherapy, (7) functional independence and mobility (Barthel index; Mahoney & Barthel, 1965).	—

Countries

Germany

Contacts

Public ContactPaula Röder

Universität Leipzig

p.roeder@studserv.uni-leipzig.de+49 (0)30 7668 375 70

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 6, 2026