Influence of therapeutic local anesthesia (TLA) on the VNS
Conditions
Interventions
Group 1: Application of 100-300 mg procaine ad 250 ml 0.9% NaCl over 60 minutes. The first recording of the time- and frequency-dependent HRV parameters was done before the application over 5 minutes
Sponsors
Universitätsklinikum Mannheim: Klinik für Anästhesie, Operative Intensivmedizin und Schmerztherapie
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: - no diabetes mellitus 1 or 2 - Not taking any medication affecting the autonomic nervous system e.g. ß-blockers, antiarrhythmics etc. - No previous cardiovascular disease (e.g., sic-sinus, AV block, atrial fibrillation, etc.) - Age between 18 and 80 years - Patient in the pain outpatient clinic of the University Hospital Mannheim - Therapy with TLA planned
Exclusion criteria
Exclusion criteria: - Minors - adults incapable of giving consent - Further, patients who object to the above inclusion criteria or do not give consent for inclusion in the study are to be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint of the study is to assess the influence of the intravenously applied short-acting local anesthetic procaine on the VNS using HRV. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary endpoint of the study is to determine the clinical applicability of HRV as a tool to detect the systemic effects of procaine. | — |
Countries
Germany
Contacts
Public ContactJustus Benrath
Universitätsklinikum Mannheim
Outcome results
None listed