I69.3
Conditions
Interventions
Group 1: Patients with left hemispheric stroke and aphasia will complete a 30 hours of a BCI-based language training (Breitenstein et al. (2017) four days per week (Teasell et al. 2018
Brady et al. 2016). The training consists of many short runs of 30 seconds to one minute each. Each run begins with a set of cues played through speakers or headphones. Only one word can complete the
Sponsors
Uniklinik Freiburg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: aphasia (confirmed using the Aachen Aphasia Test [AAT]) aged between 18-80 the presence of aphasia in AAT right-handed first-ever left-hemispheric ischemic stroke; time onset of stroke at least 6 months ago German as mother language sufficient (cognitive and language) functions to comply with study task and requirements
Exclusion criteria
Exclusion criteria: 1.hemorrhagic stroke 2.aphasia due to right hemispheric stroke 3.more than one stroke or other structural brain lesion (tumor, trauma) in MRI 4.high cerebral microangiopathy 5.high cerebral artery stenosis 6.implanted medical devices or intracranial ferromagnetic objects 7.skull lesions 8.mild/severe cognitive impairment and other medical 9.neurological or psychiatric disorders interfering with participation and/or alter the interpretation of behavioral/imaging data (e.g. endogene depression, Morbus Parkinson) 10.patient is early bilingual or professional musician 11.hearing and visual loss
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are: the quantification and qualification of a) functional communication through the Communication Activity Log (CAL) and spontaneous speech, b) naming abilities through the Snodgrass & Vanderwart Naming Test c) cognitive abilities based on a test battery consisting of the Digit Span Test, the Block Tapping Test, the TAP and the Trail Making Test. In addition, the following will be measured in the pre- and post-training : a) maximum amplitudes, latency and onset of different event-related potentials (especially P300 and N200) b) functional connectivity and c) structural connectivity . | — |
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is the language perfromance on the Aachen Aphasia Test (AAT), the most widely used standardised aphasia test in Germany. This test is administered by a speech therapist before, after and 3 months after the training. Individual changes in language functions are evaluated on the basis of the AAT manual. The T-transformed scores of the AAT subtest results (a standardisation in which the scores are transferred to a scale with a mean of 50 and a standard deviation of 10) will be compared by repeated-measures analyses of variance between the groups, across the different measurement time points (pre, post and follow-up). If necessary, the Greenhouse Geisser (G-G) correction is applied. | — |
Countries
Germany
Contacts
Public ContactMariacristina Musso
Klinik für Neurologie und Neurophysiologie
Outcome results
None listed