Patients undergoing bronchoscopy with transbronchial biopsy in the Department of Pneumology at the University Hospital Freiburg. This includes patients after lung transplantation (single or double lung transplantation) who undergo surveillance bronchoscopy.
Conditions
Interventions
Group 1: Study participants will have a sample of lung tissue taken during an already scheduled procedure, so there is no further intervention, stress or risk to study participants. All study tests t
Sponsors
Universitätsklinikum Freiburg, Klinik für Thoraxchirurgie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients undergoing bronchoscopy with transbronchial biopsy in the Department of Pneumology at the University Hospital Freiburg. This includes patients after lung transplantation (single or double lung transplantation) who undergo surveillance bronchoscopy.
Exclusion criteria
Exclusion criteria: none
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Establishment of an ex vivo spheroid cell culture model from transbronchial biopsies. - Evaluation of the antifibrotic effect of CD26/DPP4 inhibition in pulmonary tissue after lung transplantation in this model. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Evaluation of CD26/DPP4 expression and cellular composition of the obtained spheroid cell cultures. - Correlation of the fibrotic potential of the spheroid cell culture with chronic lung allograft dysfunction (CLAD)-free and overall survival | — |
Countries
Germany
Contacts
Public ContactWolfgang Jungraithmayr
Universitätsklinikum Freiburg, Klinik für Thoraxchirurgie
Outcome results
None listed