The role of the glymphatic system in the development of vasospams and chronic headache after subarachnoid hemorrhage (SAH)

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00031132

Enrollment

Registered

2023-02-01

Start date

2023-03-31

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic headache after subarachnoid hemorrhage tension headache

Interventions

Group 1: patients with a SAH 1-3 years ago Group 2: patients with tension headache Group 3: healthy controls

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: >18 years - Consent to participate in the study by patient or authorized person. - Aneurysmal SAB before >12 <36 months OR diagnosis of tension headache according to International Classification of Headache Disorders (ICHD-3) diagnostic criteria OR no relevant previous disease.

Exclusion criteria

Exclusion criteria: -Relevant co-morbidities (especially dementia; headache illnesses in the medical history; brain tumor; inflammatory illnesses of the central nervous system). - Limited ability to communicate (e.g., due to language barrier or cognitive impairment) - Pregnancy, breastfeeding - MRI contraindications

Design outcomes

Primary

Measure	Time frame
quantitative measure of the glymphatic flow (due to MR-imaging)	—

Secondary

Measure	Time frame
genetic analysis of Aquaporin-4 regarding single nucleotide polymorphisms (SNPs)	—

Countries

Germany

Contacts

Public ContactJohanna Elisabeth Rümenapp

Sektion Neurologische Schmerzforschung und -therapie

johanna.ruemenapp@uksh.de004943150023911

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026