The cortical footprint of deep brain stimulation in the superolateral medial forebrain bundle (slMFB)

The cortical footprint of deep brain stimulation in the superolateral medial forebrain bundle (slMFB) - slMFB-Corticalprint

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00031120

Enrollment

Registered

2023-01-24

Start date

2023-01-01

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F33

Interventions

Group 1: Step 1: Up to three sessions with experimental measurements (EEG + DBS under therapeutic stimulation frequency or under single DBS pulses). 2nd step: One experimental measurement with EEG and

Eligibility

Sex/Gender

All

Age

20 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Diagnosed with MDD or with OCD 2. Received bilateral slMFB-DBS, that is applied chronically for at least 1 year 3. Able to give written informed consent 4. Compliance to participate in the study 5. Stable drug regimen at least 3 weeks before study entry

Exclusion criteria

Exclusion criteria: 1. Acute psychosis assessed by a psychiatric physician. 2. Patient incapable to follow and perform the task instructions.

Design outcomes

Primary

Measure	Time frame
Aim 1: To describe the cortical effects of slMFB-DBS in a chronic stimulation setting, Aim 2: To determine whether these effects (Aim 1.) respond to different DBS stimulation patterns.	—

Secondary

Measure	Time frame
Statistically significant differences in oscillatory activity between DBS OFF and DBS ON (high frequency stimulation)	—

Countries

Germany

Contacts

Public ContactJoana Pereira

Universitätsklinikum Freiburg

joana.pereira@uniklinik-freiburg.de+49 761 270 50390

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 7, 2026