R29.5
Conditions
Interventions
Group 1: Experimental group: 2x15 min optocinetic stimulation simultan to bi-hemispheric parietal applied transcranial direct current stimulation 3 times a week for two weeks (in total: 180 min traini
Sponsors
Kliniken Beelitz GmbH
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: • Ischemic or hemorrhagic right hemispheric stroke (confirmed by imaging) • Early subacute phase ( patients must meet one of the following criteria (to exclude patients with only very mild neglect symptoms): a) saccades position test: > 4 errors b) digital desk test: searching time > 20% slower on the left compared to the right side c) mean score in line bisection test: > 2 cm deviation from the center d) copy task: < 7 points in drawing test • sufficient head control and able to sit • Sufficient vigilance for study participation • Patient should be able to understand the study - with appropriate explanation - and must be able to provide consent. If necessary, relatives or caregivers can be consulted to assist in the decision-making process or to provide consent for the patient.
Exclusion criteria
Exclusion criteria: • Previous stroke • Extensive posterior infarct with complete hemianopsia • Visual disturbances due to ocular muscle palsy • visual acuity for near vision worse than 30% (measured for better eye or binocular) • Patient with stroke in the brain stem with vestibulo-ocular symptoms • Epilepsy • Severe cognitive deficits • Severe traumatic brain injury (presen/past), recent head surgery, craniectomy, metal implant in brain • Pacemaker • Psychotropic medications, GABAergic supplements (L-DOPA, SSRI and antiepileptic drugs due to non-epileptic indication are allowed at a constant dose) • Pregnancy • History of severe alcoholism or substance abuse, severe psychiatric illness such as depression, psychosis (if not in remission) • participation in other intervention studies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eyemove©: comparison of the number of errors (left, right) before and after training in the test "Saccade position" | — |
Secondary
| Measure | Time frame |
|---|---|
| Pre-post changes a) in the test "Saccade position" two weeks after end of training b) in the performance of other applied neglect tests (line bisection, cross out lines, digital „desk test“, copy figures, Bell’s test, Apple test) c) in every day live performance (self and third-party rating: Catherine Bergego Scale) d) in associated symptomes (subjective visual vertical perception, head tilt) e) in working memory (span tasks: number, blocks) f) in electrophysiological profile (power spectra, inter- and intrahemisperial connectivity) Explorative: i) correlation between nerve growth factor BDNF in serum with tDCS and rehabilitation outcome ii) association between electrophysiological parameters and rehabilitation outcome | — |
Countries
Germany
Contacts
Public ContactNadine Külzow
Neurologische Fachkliniken, Kliniken Beelitz GmbH
Outcome results
None listed