Fructose malabsorption and serotonin-associated psychological symptoms in children and adolescents

Fructose malabsorption and serotonin-associated psychological symptoms in children and adolescents - FIPsy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00031047

Enrollment

Registered

2023-01-25

Start date

2018-01-02

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fructose malabsorption and accompanying serotonin-associated psychological symptoms

Interventions

Group 1: Patients with fructose malabsorption At first the “DISYPS- III FBB-SCREEN”, an external-rating screening questionnaire of the German “Diagnostic System of Mental Disorders in children and ad

Eligibility

Sex/Gender

All

Age

4 Years to 18 Years

Inclusion criteria

Inclusion criteria: Study group 1: Fructose malabsorption Study group 2: Combination of fructose and lactose malabsorption

Exclusion criteria

Exclusion criteria: Control sample: Exclusion of intestinal fructose malabsorption and exclusion of a combination of fructose and lactose malabsorption

Design outcomes

Primary

Measure	Time frame
The present study is based on the consideration that children and adolescents with an untreated fructose malabsorption may suffer from concomitant psychological symptoms, which are associated with a reduced intestinal absorption of tryptophan and therefore dysregulated processes of the serotonergic system. More precisely, it is hypothesized that children and adolescents with fructose malabsorption more likely show heightened serotonin-associated psychological symptoms (scales "anxiety", "depression" and "obsessive-compulsive disorder/tic" of a screening questionnaire) than externalizing ones ("attention-deficit/hyperactivity disorders" and "oppositional defiant and conduct disorders" of the screening questionnaire). Additionally, it is hypothesized that fructose-malabsorbers would show higher levels of serotonin-associated internalizing psychological symptoms than a healthy control group.	—

Measure

Time frame

The present study is based on the consideration that children and adolescents with an untreated fructose malabsorption may suffer from concomitant psychological symptoms, which are associated with a reduced intestinal absorption of tryptophan and therefore dysregulated processes of the serotonergic system. More precisely, it is hypothesized that children and adolescents with fructose malabsorption more likely show heightened serotonin-associated psychological symptoms (scales "anxiety", "depression" and "obsessive-compulsive disorder/tic" of a screening questionnaire) than externalizing ones ("attention-deficit/hyperactivity disorders" and "oppositional defiant and conduct disorders" of the screening questionnaire). Additionally, it is hypothesized that fructose-malabsorbers would show higher levels of serotonin-associated internalizing psychological symptoms than a healthy control group.

—

Secondary

Measure	Time frame
Furthermore, the degree of symptom expression is assumed to be related to eating behavior. It is expected, that within the group of children and adolescents with fructose malabsorption, the quantity of fruit sugar consumption would correlate with the degree of serotonin-related psychological symptoms.	—

Countries

Germany

Contacts

Public ContactAnnabel Maurer

Institut für Psychologie, Goethe-Universität Frankfurt

annabel.maurer@fipsy-studie.de+49 (0) 69 798 35321

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 5, 2026