Z94.0
Conditions
Interventions
Group 1: Donors: urinary protein-to-creatinine ratio (UPCR), chronic lesions in pre-implant kidney graft biopsies
Kidney transplant recipients: estimated glomerular filtration (eGFR), UPCR, death/graf
Sponsors
Medizinische Universität Wien
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Harvesting of the donor kidney in Austria - Allocation of the donor kidney to Austria - Transplantation of the kidney - Donor Age =18 years - Recipient Age =18 years - Sufficient biomaterial (pre-implant biopsy and donor urine) to perform the pre-defined analyses - Written informed consent of recipients for assessment of follow-up
Exclusion criteria
Exclusion criteria: - Withdrawal of consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Association of UPCR with histologically assessed chronic lesion in pre-implant kidney graft biopsies (chronic lesion score) Timing: the BX is done in the operating room before the implantion of the graft; method: punch biopsy, paraffin embedding; standard staining | — |
Secondary
| Measure | Time frame |
|---|---|
| - Association of UPCR with graft function after transplantation including serum creatinine, estimated glomerular filtration rate, UPCR, graft loss and death - the association of UPCR with chronic lesion of each individual compartment (glomerulosclerosis, arteriosclerosis/arteriolosclerosis, interstitial fibrosis and tubular atrophy) | — |
Countries
Austria
Contacts
Public ContactGregor Bond
Medizinische Universität Wien
Outcome results
None listed